When God calls you, he will protect his purpose that he has called you to fulfill. Satan will stop at nothing to allow people in your life to try and interfere with his purpose; however, God will not allow this to happen. He is God, and whatever he ordains to be fulfilled, it will be, as long as you stay in obedience and yield to his will. The Lord assures you that heaven and earth will pass away, but my words will never pass away (Matthew 24:35).
The reason some people leave your life is because they would have interfered with his purpose. Although this may be a hurtful experience when they leave, let them go! If they were destined to be a part of your purpose, then they would have no doubt stayed with you. Although you may not see it now; in the end you will realize that they would have interfered with what God wants you to do. Notwithstanding, God will replace the people who have left you with people of purpose who will support the calling that God has placed upon your life.
And we know that in all things God works for the good of those who love him, who have been called according to his purpose (Romans 8:28). When God calls you out of the world, do not expect that people are going to love you because you are following God and fulfilling his purpose for your life. The world would love you as one of its own if you belonged to it, but you are no longer part of the world. I chose you to come out of the world, so it hates you (John 15:19).
All things considered, you may not see the hearts of people, because you are looking on the outward appearance; therefore, you do not know that they would have become a hindrance to his purpose. However, the Lord does not look at the things people look at. People look at the outward appearance, but the Lord looks at the heart (1 Samuel 16:7). That is why God will let people leave your life, in order to protect his purpose that he has called you to fulfill.
Enough Tribulations Peace & Deliverance Ministries 
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